Monday, 22 January 2018

Comorbidties and smoking, what can we do about them?

The elephant in the room is comorbidities such as hypertension, diabetes, obesity, metabolic syndrome and smoking. How can we get pwMS to take their general health seriously? 



In the study below physical comorbidity was not only associated with disability but with each additional comorbidity, there was a mean increase in the EDSS score of 0.18. By optimising your general health you will reduce your chances of getting worse. 

When last have you been to your family doctor, or GP, to have your blood pressure, weight, blood sugar and lipids checked? If you haven't had these done in the last 12 months you should go and get them done. 

Are you still a smoker? If yes, you need to read the second paper below that shows smoking reduces the effectiveness of interferon-beta. I wouldn't be surprised if this observation extends to other DMTs. We know that pwMS who smoke do worse than non-smokers. So if you want to improve your outcome you need to stop smoking. Please note you don't have to necessarily give up your nicotine habit. You can get your daily fix of nicotine from several other safer options (gum, skin patches, tablets, e-cigarettes, etc.). 

COMORBIDITIES

Zhang et al. Effects of physical comorbidities on disability progression in multiple sclerosis. Neurology. 2018 Jan 3. pii: 10.1212/WNL.0000000000004885.

OBJECTIVE: To examine the association between physical comorbidities and disability progression in multiple sclerosis (MS).


METHODS: We conducted a retrospective cohort study using linked health administrative and clinical databases in 2 Canadian provinces. Participants included adults with incident MS between 1990 and 2010 who entered the cohort at their MS symptom onset date. Comorbidity status was identified with validated algorithms for health administrative data and was measured during the 1 year before study entry and throughout the study period. The outcome was the Expanded Disability Status Scale (EDSS) score as recorded at each clinic visit. We used generalized estimating equations to examine the association between physical comorbidities and EDSS scores over time, adjusting for sex, age, cohort entry year, use of disease-modifying drugs, disease course, and socioeconomic status. Meta-analyses were used to estimate overall effects across the 2 provinces.

RESULTS: We identified 3,166 individuals with incident MS. Physical comorbidity was associated with disability; with each additional comorbidity, there was a mean increase in the EDSS score of 0.18 (95% confidence interval [CI] 0.09-0.28). Among specific comorbidities, the presence of ischemic heart disease (IHD) or epilepsy was associated with higher EDSS scores (IHD 0.31, 95% CI 0.01-0.61; epilepsy 0.68, 95% CI 0.11-1.26).

CONCLUSIONS: Physical comorbidities are associated with an apparent increase in MS disability progression. Appropriate management of comorbidities needs to be determined to optimize outcomes.

SMOKING


Petersen et al. Smoking affects the interferon beta treatment response in multiple sclerosis. Neurology. 2018 Jan 17. pii: 10.1212/WNL.0000000000004949.

OBJECTIVE: To investigate whether smoking in patients with relapsing-remitting multiple sclerosis (RRMS) treated with interferon beta (IFN-β) is associated with the relapse rate and whether there is an interaction between smoking and human leukocyte antigen (HLA)-DRB1*15:01, HLA-A*02:01, and the N-acetyltransferase-1 (NAT1) variant rs7388368A.

METHODS: DNA from 834 IFN-β-treated patients with RRMS from the Danish Multiple Sclerosis Biobank was extracted for genotyping. Information about relapses from 2 years before the start of treatment to either the end of treatment or the last follow-up visit was obtained from the Danish Multiple Sclerosis Treatment Register. Smoking information came from a comprehensive questionnaire.

RESULTS: We found that the relapse rate in patients with RRMS during IFN-β treatment was higher in smokers compared to nonsmokers, with an incidence rate ratio (IRR) of 1.20 (95% confidence interval [CI] 1.021-1.416, p = 0.027) and with an IRR increase of 27% per pack of cigarettes per day (IRR 1.27, 95% CI 1.056-1.537, p = 0.012). We found no association or interaction with HLA and the NAT1 variant.

CONCLUSION: In this observational cohort study, we found that smoking is associated with increased relapse activity in patients with RRMS treated with IFN-β, but we found no association or interaction with HLA or the NAT1 variant.

ProfG    

14 comments:

  1. At my local GP surgery there's a weighing scale and a digital blood pressure monitor, you put your arm in and it prints off a reading, all free to do. It's self service and I try and do this a couple of times a year to keep track.

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  2. Tomatoes contain nicotine, Prof G. Do you advise us to avoid them too?

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    Replies
    1. This little table shows just how negligible the amount of nicotine is, I suggest you try aubergine ;-)
      https://www.vidarholen.net/contents/junk/nicotine.html

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    2. You are assuming the problem with smoking is the nicotine, it is more likely the carbon monoxide.

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    3. I thought nicotine may even have neuroprotective properties:
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685410/

      But fags? No.

      "You may think a cigarette is just tobacco wrapped in paper, but it’s much more than that. When a cigarette burns it releases a dangerous cocktail of over 5,000 different chemicals. Many of these chemicals are poisonous and more than 70 may cause cancer, according to the International Agency for Research on Cancer (IARC). And it’s not just the smoker who is exposed to these chemicals, because there are also high levels in the smoke coming off the tip of a cigarette while it burns. So anyone around the smoker breathes them in as well."

      http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/smoking-and-cancer/whats-in-a-cigarette

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    4. "I thought nicotine may even have neuroprotective properties"

      Correct. Can be administered as a patch.

      Delete
    5. Just stumbled upon this re. nicotine - seems like it's a mixed picture in terms of effects on the body?

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/

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  3. I just wonder if the 'co-morbidity = worsening MS' message is spelled out early and clearly enough to patients. I suspect it's often interpreted as further affirmation of the 5 a day (etc.) mantra pumped out to everybody, without the sting in the tail. In truth it's a negative message - not that the MS may feel much different if you do live healthily but you'll most likely feel worse if you don't!

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  4. What about alcohol ? Moderation or zero for MS brain health ?

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  5. Low mobility worsens comorbilities :(

    What to do?

    Obrigado

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    Replies
    1. Thanks i know

      Aerobic exercise increases hippocampal volume
      and improves memory in multiple sclerosis:
      Preliminary findings

      Aerobic exercise resulted in a 16.5% increase
      in hippocampal volume (baseline = 5958 mm3,
      follow-up = 6942 mm3), a 55.9% increase in
      verbal memory (CVLT Total Learning baseline
      = 31, follow-up = 48; CVLT Long Delay
      Free Recall baseline = 7, follow-up = 11),
      and 51.3% increase in nonverbal memory
      (BVMT Total Learning baseline = 18, followup
      = 23; BVMT Delayed Recall baseline = 4,
      follow-up = 7). Additionally, a large increase in
      hippocampal resting-state functional connectivity
      was shown (see Figure 1, bottom panel). VO2 peak
      increased by 10% (baseline = 20.2 ml/kg/min,
      follow-up = 22.3 ml/kg/min).

      I was thinking about, those pwms with with low mobility unable to exercise for longer periods of time

      Obrigado

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  6. Interesting papers. Shame Zhang et al. only looked at EDSS as an outcome measure, since this only considers mobility when allocating the higher scores. They might have seen an even more pronounced effect if they had been considering the other things that go wrong in pwMS (bladder issues, hand control, eyesight problems, speech issues, cognitive issues and so on, and on). Personally, I hate the EDSS.

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