Tuesday, 6 February 2018

Education: About EBV Infection

A post for people who need to know more about EBV.




EBV is a member of the herpes family of viruses that are common in humans. 

The silent infection and the life-long persistence are the keys to the widespread infection of EBV in the human population. 

In most individuals, EBV infection occurs early in childhood and goes unnoticed.

In contrast, delayed primary infection during adolescence can lead to infectious mononucleosis (IM) = glandular fever. 

EBV primarily targets and remains latent in memory B cells. 

Depending on the type of latency, EBV expresses different sets of latent products. 

In the latency typically seen in IM, up to 12 viral products, including 6 EBV-encoded nuclear antigens (EBNA-LP, EBNA1, EBNA2, EBNA3A, EBNA3B, and EBNA3C), 3 latent membrane proteins (LMP1, LMP2A, and LMP2B) and large quantities of 2 non-coding RNAs (EBERs) are expressed 

A small percentage of latently infected cells intermittently enter the lytic cycle resulting in the release of viral particles

This transition from latency to lytic cycle is triggered by the expression of two immediate early viral proteins, BZLF1 and BRLF1

Almost all MS patients are infected with EBV compared to ~95% non-MS controls

Thus, EBV seronegative individuals have almost zero risk of developing MS. 

However, a dramatic upsurge in MS risk is seen when these individuals seroconvert following EBV infection

Furthermore, individuals who have a history of EBV-associated IM have also been shown to be at increased risk of developing MS.

In the paper below

Overall, 91/101 (90%) of MS cases were EBV positive by l compared to only 5/21 (24%) non-MS cases 

1 comment:

  1. There are people who prefer, for example, to "believe" in CCSV than in the real possibility of us with MS being infected with a virus that somehow discovers a "weakness in us" and manages to paralyze us over time.
    It even appears that EBV needs cholesterol for its lytic phase.

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