Complaints about Δ9-tetrahydrocannabinol (THC):cannabidiol (CBD) oromucosal spray (Sativex®; GW Pharma Ltd, Sailsbury, UK) in the management of multiple sclerosis spasticity include unpleasant taste and oral mucosal anomalies. This pilot study assessed the use of sugar-free chewing gum and/or a refrigerated bottle of THC:CBD oromucosal spray to mitigate these effects.
MATERIALS & METHODS:
Patients with multiple sclerosis spasticity (n = 52) at six sites in Italy who were receiving THC:CBD oromucosal spray and had associated oral mucosal effects were randomized into Group A (chewing gum; n = 15); Group B (cold bottle; n = 20); and Group C (cold bottle + chewing gum; n = 17).
Taste perception in patients receiving chewing gum ± cold bottle intervention (Groups A and C combined) was significantly (p = 0.0001) improved from baseline to week 4 while maintaining spasticity control.
Patient comfort, satisfaction and treatment adherence may benefit from these interventions
This article may be useful to anyone who gets sativex. Sativex is an alcoholic extract of cannabis (i.e a tincture), I thik with a peppermint flavour, so it is like a Creme-de-Menthe spray under the toungue. However, as it is reletively pure alcohol,means that it is going to be a fixative to the inside of the cheek and it is going to taste unpleasant. We know this because in the placebo controlled tirals where people could have 0-20+ puffs of the sativex inhaler and those on placebo where there is no drug to work, should have been puffing away, but they didn't ,and on average had lesss than a half of available. This says the taste isn't good. However, above may be some use if you can get access to treatment