Monday, 18 June 2018

Happy Anniversary Prof G

It is 25 years to the day that I arrived in London to start my PhD on body fluid biomarkers in MS. 

What has changed in the last 25 years?

Stornoway research day series: Self-management

MS Specialist Nurse for the Western Isles, Rachel Morrison, talks about the importance of self-management in multiple sclerosis. And she covers some top tips for managing your own condition.

Sunday, 17 June 2018

Stornoway research day series: Understanding your MS symptoms

Dr Stewart Webb defines what multiple sclerosis is, and what's going on in the body when you feel certain MS symptoms. 

Saturday, 16 June 2018

Stornoway research day series: How nutrition and exercise can make a difference

Our Glasgow colleague Dr Sarah Martin discusses different diets that claim to improve MS symptoms in this talk for the people with MS and their families on the Western Isles.

Friday, 15 June 2018

Stornoway research day series: What makes up the neurologist's toolkit?

Neuro Doc Gnanapavan discusses the ways that neurologists currently diagnose and monitor MS in their patients. 

New primary progressive study - ORATORIO-HAND

Yesterday there was a press release from Roche announcing ORATORIO-HAND a new phase 3 trial in people with PPMS, but only this time recruitment will extend beyond EDSS 6.0 up to EDSS 8.0, i.e. wheelchair users. The primary outcome will be the 9-hole peg test.

For people in the field of MS, the announcement of the ORATORIO-HAND trial represents a milestone in the history of MS. It challenges the dogma that once you have more advanced MS (progressive disease) that you are 'irredeemable' and sends a message of hope to all people with MS in wheelchairs that we haven't forgotten you.

I hope that our long-running #ThinkHand campaign will play a part to play in getting the wider MS community and other relevant stakeholders behind this study.

Alison Thomson presenting our #ThinkHand campaign at the 2016 MS Trust Conference 

Thursday, 14 June 2018

Stornoway research day series: Current and upcoming treatments

Another talk from our Stornoway research day series. Here, Dr Pushkar Shah talks about multiple sclerosis treatments that are currently available, and ones that are being developed. 

NIH Grand Round: what is an IRT?

As promised the following is my slide deck from my presentation at the NIH grand round on Tuesday morning (12-June-2018). I was surprised to find out that none of the MSologists at the NIH prescribe DMTs; they leave the decision up to the treating neurologist. The NIH MSologists only see patients as part of research protocols. However, the resources at their disposal for research is quite extraordinary. They are a very privileged group of researchers.

After the meeting, someone asked me what excites me most about MS research at the moment? Can you guess what I said?

Wednesday, 13 June 2018

Stornoway Research Day series: Can we prevent or slow down MS?

Dr K discusses the difference between insidious MS symptoms and ageing, progressive MS and relapsing remitting. He explains the Think Hand campaign and the research into preventing and slowing down MS.

Tuesday, 12 June 2018

NIH Charcot Lecture 2018

I delivered my Charcot lecture at the Washington Press Club, to approximately 125 people, last night. My main message was that there are compelling reasons to do MS prevention studies and if we don't start them ASAP we will be letting down the next generation of people who will develop MS. I view this as a ticking time bomb. The continual increase in the incidence of MS across the world, particularly in places like Scotland and central Canada, indicates that we have an epidemic on our hands. Don't you think we need to do something about it?

Thank you for completing the MS prevention survey; I included the results in my talk and one very touching and poignant quote.

4am knows all my secrets

Mult Scler Relat Disord. 2018 May 23;24:32-37. doi: 10.1016/j.msard.2018.05.016. [Epub ahead of print]

Analysing the relationship between polysomnographic measures of sleep with measures of physical and cognitive fatigue in people with multiple sclerosis.

Sunday, 10 June 2018

Stornoway Research Day: The mouse doctor's talk!

Here is the second in our series of the Stornoway Research Day talks. The Mouse Doc talks about how disease modifying therapies work.

Keep an eye on our Youtube channel for all the other talks.

Watch How Disease Modifying Therapies Work.

Saturday, 9 June 2018

Stornoway Research Day: The first video!

As you may remember, last month the Barts-MS and Glasgow teams went to Stornoway on the Isle of Lewis. Over two days the team gave talks to healthcare professionals and people with MS from the Western Isles.

Friday, 8 June 2018

Saúl post: Hold your horses: Are you telling me that MS can cause impulsivity?!

Neuropsychiatric disorders and cognitive impairment have a negative impact on daily functioning and quality of life of MSers. While much research has focused on comorbid depression in pwMS, less attention has been given to the association between MS and impulsive behaviour. 

Thursday, 7 June 2018

Wednesday, 6 June 2018

Atraumatic LP needles: what you need to know

This week's BMJ has a rapid recommendation piece on the advantages of using atraumatic needles in routine clinical practice. Let's hope this will now drive the necessary changes we have been arguing for, for several years. Our aim is to get neurologists and MSers to rethink CSF analysis for monitoring MS.

Tuesday, 5 June 2018

Sunday, 3 June 2018

Managing expectations: can we cure MS?

When I was at the ANZAN meeting in Darwin I was shown the results of a recent survey of Australian people with MS regarding their research priorities. The number one unmet need was for researchers 'to find a cure for MS via repair and regeneration of cells'. This is easier said than done. I also have problems linking 'an MS cure' with the concepts of 'repair and regeneration'. In this post, I try and explain why.

Although a large part of this post is repetitive from past posts, sometimes it is helpful to repeat oneself. 

Saturday, 2 June 2018

Cladribine for People with Progressive MS.There are options available

Today we provide further evidence that people with Progressive MS can respond to DMT

MS is neurodegenerative from day one to the last day and is also inflammatory from day one to the last day.

Why don't we do something about the inflammation in MS in every one?. 

Friday, 1 June 2018

Ask a Question June

If you have a question unrelated to other posts.

This is the place for you

Don't start treatment too late

Don't leave it too late before you start Treatment,

How much more evidence do we need?

ANZAN W. Ian McDonald Memorial Lecture

I have just had a very enjoyable meeting in Darwin and want to thank the Australian and New Zealand Association of Neurologists (ANZAN) for being so hospitable and for inviting me to give several talks, in particular, the Ian McDonald memorial lecture. 

The following is my presentation that you can view as a slideshow or you can download from SlideShare. I have also provided the links for you to read about Ian McDonald.

W. Ian McDonald (1933-2006)