This study does not mention much about ivermectin except to say it is "already used as an anti‐parasitic agent in humans will facilitate challenging this drug in clinical trials in that demyelinating disease".
However, I am not sure you want to do a trial in MS. This is because ivermectin is neurotoxic and kills nerves if it gets in the brain.
However, this effect is not a problem in most humans and animals because it is pumped out of the brain by a molecule called P-glycoprotein. So if it is actively pumped out of the brain, how is it going to target microglia in the brain? However saying that we showed that p-glycoprotein is lost in MS lesions so you will get a neurotoxic molecule into areas that you don't want it to go.
It must have got in the brain in these experiements I guess.
However, it is not going to do this effectively. In this study they used C57BL/6 strain mice which have P-glycoprotein (ABC-B1). Lucky this wasn't done in MF-1 strain mice, as you may well of had a dead mouse.
These mice share a feature with Collie Dogs in that they both lack P glycoprotein. This means they cannot exclude ivermectin from the brain and so exhibit neurotoxicity, if they have the drug
I was taking to some one at a cannabis conference once and they told me about a pot-grower ,who got neurological problems after spraying pot with avermectin (a homologue of ivermectin) to get rid of mites, which is a pest of pot. So my guess would be that this person was p-glycoprotein deficient and so got neurotoxicity. We'll never know.
Mitoxantrone is used in MS, but it is also neurotoxic (kills/hurts monkies when delivered intrathecally) and is actively pumped out of the brain by breast cancer resistance protein-ABC-G2), but it is used to target immune cells in the peripheral circulation, so does not have to get into the brain to do its job.
Should Ivermectin be used as a remyelination agent?.
It needs to be done in a carefully controlled situation if it is to be done at all..Don't start self-experimentation and risk neurotoxicity, just because a rodent researcher, who maybe hasn't thought about translatability, says so.