Tuesday, 9 October 2018

Cannabis as good as copaxone in animals: Two wrongs don't make a right

Avidekel Cannabis extracts and cannabidiol are as efficient as Copaxone in suppressing EAE in SJL/J mice.Gallily R, Yekhtin Z.Inflammopharmacology. 2018 Oct 5. doi: 10.1007/s10787-018-0536-3. [Epub ahead of print]
Multiple sclerosis (MS) is an autoimmune disease leading to the destruction of myelin with consequent axonal degeneration and severe physical debilitation. The disease can be treated with immunosuppressive drugs that alleviate the symptoms and retard disease aggravation. One such drug in clinical use is glatiramer acetate (Copaxone). The non-psychotropic immunosuppressive cannabinoid compound cannabidiol (CBD) has recently been shown to have beneficial effects on experimental autoimmune encephalomyelitis (EAE). The aim of our study was to compare the efficacy of CBD and standardized extracts from a CBD-rich, ∆9-THClow Cannabis indica subspecies (Avidekel) with that of Copaxone. Our data show that CBD and purified Avidekel extracts are as efficient as Copaxone to alleviate the symptoms of proteolipid protein (PLP)-induced EAE in SJL/J mice. No synergistic effect was observed by combining CBD or Avidekel extracts with Copaxone. Our data support the use of Avidekel extracts in the treatment of MS symptoms.

This is not something I would be boasting about, because although Copaxone is number one treatent for MS, the animal data that supports this use is pretty pants . 

Therefore to suggest that cannabidiol is just as good..actually says that cannabidiol is pants too. 

Of course we can get copaxone to work  but not in the way it is used in humans. 

However, we know that cannaidiol is rubbish already and we had shown it does very, very little as an immunosuppressive to inhibit EAE. Shame that others maintain the opposite. 

Either we are rubbish in how we do experiments, or they are . There is not inbetween. We tried to get cannabidiol to do something for years. Therefore Time will tell and I predict the human trials will show that it is indeed rubbish.

Tetrahydrocannabinol can induce immuomodulation in animals, but only when they are so out-of-it that we think it is meaningless for human use. However you can believe this if you want

1 comment:

  1. Yes, the cannabinoids need a lot more research, particularly in the potential side effects area! Personally, I wouldn't touch them without more research.

    ReplyDelete

Please note that all comments are moderated and any personal or marketing-related submissions will not be shown.