Antidepressants for the treatment of depression in neurological disorders: a systematic review and meta-analysis of randomised controlled trials.

Price et al. J Neurol Neurosurg Psychiatry. 2011 May 10.

There is a high prevalence of depression in PwMS and other neurological disorders. A systematic review and meta-analysis of 20 randomised controlled trials showed that anti-depressant treatment was associated with a greater than two-fold chance of remission (odds ratio = 2.23; 95% confidence interval = 1.54 to 3.23; number needed to treat=7).

"Good news is  that anti-depressants work in PwMS; bad news they are not that effective."