The neuropathological basis of clinical progression in multiple sclerosis.

Reynolds et al. Acta Neuropathol. 2011 May 28. [Epub ahead of print]

This review highlights the importance of grey matter (GM) involvement in MS, which we think contributes to a lot of the burden of disease. 

"Grey matter pathology is an increasing important area of MS research and an important target for both DMTs and symptomatic therapies. I am sure that grey matter pathology is responsible for the cognitive issues PwMS frequently notice but seldom complain about."