Discussion: In RRMS, GM and WM atrophy have distinct patterns of regional distribution, with a sparing of GM infratentorial regions. Gender, disease duration and disability affect differently the topography of GM/WM atrophy, while T2 lesions play a modest role.
This is a descriptive study, follow the links to see what each bit of the brain does. This study reports on brain shrinkage during MS. The problem of using MRI to assess shrinkage is that this can be masked by fluid accumulation.