EM, Waubant E, McCulloch CE, Okuda DT, Evangelista AA, Lincoln RR,
Gourraud PA, Brenneman D, Owen MC, Qualley P, Bucci M, Hauser SL,
Pelletier D.Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis. Ann Neurol. 2012 Aug;72(2):234-40. doi: 10.1002/ana.23591.
sought to determine whether vitamin D status is associated with
developing new T2 lesions or contrast-enhancing lesions on brain
magnetic resonance imaging (MRI) in relapsing multiple sclerosis (MS).
EPIC is a 5-year longitudinal MS cohort study at the University of
California at San Francisco. Participants had clinical evaluations,
brain MRI, and blood draws annually. From the overall cohort, we
evaluated patients with clinically isolated syndrome or
relapsing-remitting MS at baseline. In univariate and multivariate
(adjusted for age, sex, ethnicity, smoking, and MS treatments) repeated
measures analyses, annual 25-hydroxyvitamin D levels were evaluated for
their association with subsequent new T2-weighted and
gadolinium-enhancing T1-weighted lesions on brain MRI, clinical
relapses, and disability (Expanded Disability Status Scale [EDSS]).
A total of 2,362 3T brain MRI scans were acquired from 469 subjects. In
multivariate analyses, each 10ng/ml higher 25-hydroxyvitamin D level
was associated with a 15% lower risk of a new T2 lesion (incidence rate
ratio [IRR], 0.85; 95% confidence interval [CI], 0.76-0.95; p = 0.004)
and a 32% lower risk of a gadolinium-enhancing lesion (IRR, 0.68; 95%
CI, 0.53-0.87; p = 0.002). Each 10ng/ml higher vitamin D level was
associated with lower subsequent disability (-0.047; 95% CI, -0.091 to
-0.003; p = 0.037). Higher vitamin D levels were associated with lower,
but not statistically significant, relapse risk. Except for the EDSS
model, all associations were stronger when the within-person change in
vitamin D level was the predictor.
Vitamin D levels are inversely associated with MS activity on brain
MRI. These results provide further support for a randomized trial of
vitamin D supplementation
The lower the Vitamin D levels the more MS activity on brain
MRI was detected. Further reason to supplement
Labels: Vitamin D