Brain atrophy our next therapeutic target. #MSBlog #MSResearch
"The following are the final brain atrophy survey results. They are very interesting."
"It is clear that there is a knowledge gap, between what you want to know about your disease and what your neurology team are prepared to provide you, or they do not have the data to give you. The only way we are going to get brain atrophy up the agenda is for you to ask your neurologist about whether or not you have evidence of brain atrophy on your MRI. Unless the atrophy is gross atrophy, i.e. visible to the naked eye, most neurologists won't be able to say yes or no. Brain atrophy on MRI has to be measured using specialised software and normalised to a reference data set, or to an MRI you have had in the past."d
"We at the Royal London Hospital don't get routine brain atrophy measurements. We have however, been collecting the correct data set to allow brain atrophy measurements. This is a so called 3D-acquisition, which will allow us to measure brain atrophy serially in MSers. Why will this be important? I think it will be one of the metrics that we include in the NEDA (no evidence of disease activity) composite. We will not only aim to prevent relapses, disease progression, new or enlarging T2 and Gd-enhancing lesions, but we will also aim to normalise the rate of brain atrophy. Brain atrophy is not a good thing and correlates with a poor outcome so preventing it should benefit MSers."
Labels: brain atrophy, survey results