Sunday, 19 April 2015

Diagnosis Children with MS

Heussinger N, Kontopantelis E, Gburek-Augustat J, Jenke A, Vollrath G, Korinthenberg R, Hofstetter P, Meyer S, Brecht I, Kornek B, Herkenrath P, Schimmel M, Wenner K, Häusler M, Lutz S, Karenfort M, Blaschek A, Smitka M, Karch S, Piepkorn M, Rostasy K, Lücke T, Weber P, Trollmann R, Klepper J, Häußler M, Hofmann R, Weissert R, Merkenschlager A, Buttmann M; GRACE-MS (German-speaking Research Alliance for ChildrEn with MS).Oligoclonal bands predict multiple sclerosis in children with optic neuritis. Ann Neurol. 2015. doi: 10.1002/ana.24409. [Epub ahead of print]

We retrospectively evaluated predictors of conversion to multiple sclerosis (MS) in 357 children with isolated optic neuritis (ON) as a first demyelinating event who had a median follow-up of 4.0 years. Analsysis revealed abnormal cranial magnet resonance imaging (cMRI; HR 5.94; 95% I: 3.39-10.39; p<0.001), presence of cerebrospinal fluid oligoclonal IgG bands (OCB; HR 3.69; 95% CI: 2.32-5.86; p<0.001) and age (HR 1.08 per year of age; 95% CI: 1.02-1.13; p=0.003) as independent predictors of conversion while sex had no influence. Combined cMRI and OCB positivity indicated a 26.84-fold higher HR for developing MS compared to double negativity (95% CI: 12.26-58.74; p<0.001). Accordingly, cerebrospinal fluid analysis may supplement cMRI to determine the risk of MS in children with isolated ON.

This study says if you have MRI and oligoclonal band data it helps working out the risk of a child developing MS.

1 comment:

  1. They don't look like children. They look like they're in their twenties.


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