Saturday, 25 July 2015

Are some EAE papers just pain wrong?

Silva JV, Oliveira BF, Nascimento OJ, Farinhas JG, Cavaliere MG, Cal Hde S, Matta AP. Increased multiple sclerosis relapses related to lower prevalence of pain. Arq Neuropsiquiatr. 2015;73:593-600.
Objective The study aims to investigate the presence of pain amongst multiple sclerosis (MS) patients. 
Method One hundred MS patients responded to questionnaires evaluating neuropathic and nociceptive pain, depression and anxiety. 
Results Women had a statistically higher prevalence of pain (p = 0.037), and chances of having pain after the age of 50 reduced. Women with pain had a statistically significant lower number of relapses (p = 0.003), restricting analysis to those patients with more than one relapse. After the second relapse, each relapse reduced the chance of having pain by 46%. Presence of pain was independent of Expanded Disability Status Scale (EDSS) anxiety, and depression. 
Conclusion Our findings suggest a strong inverse association between relapses and pain indicating a possible protective role of focal inflammation in the control of pain.
Yesterday we had this EAE paper saying that relapses were caused by pain. 

Yet they said there was no evidence of pain relating to relapse  in MS and so it is quite apt that this paper comes along one day later and says what a load of jajce. 

Relapses were associated with less pain and one maybe thinks that attacks are associated with damage that means sensation is lost.


  1. "and chances of having pain after the age of 50 reduced"

    Any ideas why after the age 50 chances of having pain is reduced? And is that at age 51 or 50 plus 3, 6 or 8 months etc? But not 49 and 7 months (my age with hideous TN pain)? Age 50 seems quite miraculous, if it can do this.

  2. Look how nice it is!! First Brazilian study on MS that I see here on the blog since I started to accompany him every day... But here doing science is not easy, lack incentive and the bureaucracy is absurd...Yet regarding the pain I only know I felt a lot of pain at the beginning and throughout the outbreak ...


Please note that all comments are moderated and any personal or marketing-related submissions will not be shown.