Rio score | |
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MRI criterion = 1 | if the patient had (on the yearly MRI scan) > 2 active T2 lesions, defined as new or enlarging T2-weighted lesions, plus the number of gadolinium-enhancing (Gd) T1-weighted lesions over the first year |
Relapse criterion = 1 | if the patient experienced ≥ 1 relapse over the first year |
EDSS criterion = 1 | if there was an increase in the patient’s EDSS score of ≥1 point, sustained over at least 6 months and confirmed at the end of the follow-up period. |
The sum of these three criteria classifies patients into those having a score of 0, 1, 2 or 3 | |
Modified Rio score | |
MRI criterion = 1 | if the patient has had > 4 new T2 lesions |
Relapse criterion = 1 | if the patient experienced 1 relapse |
Relapse criterion = 2 | if the patient experienced ≥ 2 relapses |
Score = 0 | if new T2 lesions ≤ 4 and relapses = 0 |
Score = 1 | if new T2 lesions ≤ 4 and relapses = 1; or new T2 lesions >4 and relapses = 0 |
Score = 2 | if new T2 lesions ≤ 4 and relapses ≥ 2; or new T2 lesions >4 and relapses = 1 |
Score = 3 | if new T2 lesions > 4 and relapses ≥ 2 |
Labels: relapses, Rio criteria, sub optimal treatment response, T2 lesions