Wednesday, 14 September 2016

Education: Understand MS down the plug hole model of MS

Yesterday ,we described a model of MS presented to researchers, as a draining pond with lesions creating mini volcanoes.

This is based on recent article (click here)

To help us understand the pictures they gave us some videos too.

You may find them useful too.


In this video depiction of RRMS with early secondary progressive disease, relapsing disease transitions to SPMS with disability being driven in the early years by relapse  (“base effects”) and in the later years primarily by the declining threshold (“surface effects”).
Highly active RRMS
In this video depiction of RRMS, highly active disease is characterized topographically by extensive clinical and sub-clinical inflammatory activity. Several lesions in the spinal cord and brainstem do not resolve below the clinical threshold, demonstrating lesions with high degree of severity and low capacity for recovery.
Mild RRMS with limited disability accumulation
In this video depiction of mild RRMS, no demonstrable disability is accumulated at 20 years of disease. All relapses resolve below the clinical threshold—demonstrating lesions with a high recovery capacity—and there is little depletion of functional reserve beyond that of normal aging.
In this video depiction of PPMS, several sub-threshold lesions, denoting underlying disease activity, do not cross the clinical threshold until functional reserve declines. Disability is driven over time by the dropping threshold.


  1. Why is are there no "unhelpful", "very unhelpful" and "extremely unhelpful" boxes to check? This would be more scientific.

    1. Because trolls used to spend all their time ticking unhelpful, so it seemed sensible to remove their fun as surely they have better things to do.

  2. "A hypothesis driven biologically informed model could build on the clinical phenotypes to encompass the dynamic admixture of factors underlying MS disease course".

    Then according to the latest publications there is a different manifestation of MS even dependent on biological questions phenotype? And the T cells would respond to various antigens, which thereafter forward the same answer and that would cause what we know as MS?

  3. Dr. G - here is the link to the article you're discussing:

    (You accidently posted the wrong link).


Please note that all comments are moderated and any personal or marketing-related submissions will not be shown.