Savin et al. Effect of Fampridine-PR (prolonged released 4-aminopyridine) on the manual functions of patients withMultiple Sclerosis. J Neurol Sci. 2016 Jan 15;360:102-9.
BACKGROUND: Persons with MS (PwMS) commonly present ambulatory and manual dysfunctions. While ambulation is recognized as important to PwMS, manual dysfunction is only lately gaining attention. Fampridine-PR was approved for MS ambulatory impairments. Anecdotal evidences indicate possible therapeutic effects on manual function.
OBJECTIVE: To comprehensively assess the effect of Fampridine-PR on manual functions of PwMS.
METHODS: Twenty six PwMS with ambulatory and manual dysfunction assessed before, 1 and 3 months after treatment with Fampridine-PR, applying Timed 25-Foot Walk (T25FW) for ambulation while manual functions were evaluated by several tools addressing the International Classification of Functioning (ICF) concepts. This includes hand grip and pinch strength, 9 Hole Peg Test (9HPT), Arthritis Hand Function Test (AHFT), activities of daily life (ADL) tests, ABILHAND questionnaire and Computerized Penmanship Evaluation Tool (ComPET).
RESULTS: Fampridine-PR increased dominant hand grip and pinch strength 1-month following treatment initiation by 12% and 10% (p<0.05), respectively. 9-HPT improved by 11.3% after 3-months of treatment (p<0.05%) and ABILHAND improved by 16% and 31% (p<0.05%) after 1 and 3-months of treatment. Mean stroke duration in air of the name writing task improved by 21% (p<0.05) following 3-months of treatment. T25FW results were similar to previous reports.
CONCLUSION: The results of this pilot study suggest that Fampridine-PR improves manual function of PwMS. Methods herein indicate that an integrative approach may be useful for evaluation of manual function in MS and in additional neurological diseases.