This study offers some support when analysis of people with MS undertaking HSCT was done. In this 80% of people had progressive MS and disability progression was stoped in about 50% of 5 people up to 5 years of analysis. It will take longer follow-up to see if this is sustained but based on the data below people continue to fail so at 10 years the progression free cohort only makes up about 30 percent. As you can see if you were relapsing verses progressive you were about two-three times as likely to see benefit.
So it says 50% of people progressed and tells me we need more than peripheral immunosuppression. I suspect you need to deal with inflammation in the brain. It also says that nearly 3% of people didnt make it, so it is not something you should do with your eyes closed. However in more recent studies this risk of mortality has reduced.
As one of the readers says "Graph C (below) indicates that no-one with PPMS did not progress past 5 years so it sort of says do not expect miracles of anyone taking this treatment, given the risks is this really any better than other DMT?"
You need to be clear what the risks are and the competence and success of centres where you may undergo this . The types of HSCT was not all the same and (17.4% [49 of 281] low intensity, 63.7% [179 of 281] intermediate intensity, and 18.9% [53 of 281] high intensity treatment regimes.
The data raise the possibility that AHSCT may have reduced the risk of disease progression in the treated patients, yet demonstration is lacking in the absence of a control group.
The incidence of new autoimmune disease was 5.0% (14 of 281), but considerably lower than after lymphocyte-depleting treatment with alemtuzumab, which approaches a risk of 50%.,
It is open access so have a read.