Don't formulate, or take, DIY-BG12. #MSblog #MSResearch
"Some of you may have have already clicked through the link (DMF DIY), that was posted yesterday on the blog, in a comment, and read the DIY instructions on how to formulate your own version of dimethyl fumarate or BG12 (Tecfidera)."
"I need to stress that this is not something you should be doing. DMF is being used in pharmacological doses and has a toxicity profile that needs to be monitored closely There is no way to be sure if there are any impurities in this DIY-formulation. Commercial grade chemicals are not pure enough to be used in pharmacological preparations. The impurities may cause serious problems. The reason why the Pharma industry is so heavily regulated is to ensure the drugs that are sold meet strict quality guidelines and that there are no impurities in them."
"Some of you, as usual, will accuse me of supporting Pharma, which is definitely the case. Pharma is really the only show in town and without them drug innovation will grind to a halt. In addition, I have a responsibility to ensuring that the MSers in my care are safe and not taking any undefined risks, which you will be doing by self-formulating and taking DIY DMF capsules."
Other posts of interest:
23 Jan 2013
"In response to the intense interest on the blog concerning Fumaderm and PML and its possible implications for BG12, we invited Professor Doctor Ralf Gold to contribute a guest post on this topic! I hope it answers some of ...
20 Jan 2013
Therefore there has only been 4 reported cases of PML on Fumaderm, one of which was on Efalizumab a known cause of PML, and one new case on a compounded formulation of fumarate. I hope this clarifies things for our ...
13 Jan 2013
"A form of BG-12 called fumaderm has been used in psoriasis for many years with no major adverse events emerging. I assume the FDA has looked at fumaderm's long-term safety profile and the BG-12 MS data and felt an ...
Labels: BG12, dimethylfumarate, DMF